Dr. Chen and her collaborators are conducting an interdisciplinary study of biological, social, economic and environmental determinants of trajectories of health and functional outcomes in women in the transitional years from middle to later adulthood under an NICHD grant to UNC Chapel Hill. The goal is to identify early adult risk factors related to increased risk of chronic disease, disability, and cognitive decline and protective factors related to maintenance of heath and a high level of functioning in a cohort of Filipino women. The research team is studying participants in the Cebu Longitudinal Health and Nutrition Survey (CLHNS). This community-based study of mother-child pairs began in 1983 with the recruitment of 3,327 pregnant women (aged 14-47) from 33 randomly selected urban and rural communities of Metro Cebu, the second largest and fastest growing metropolitan region of the Philippines. Multiple surveys through 2007 provide a wealth of detailed community, household and individual level information. In 2007, women were 38-71 years old; 45% were 50-60 and 10% were >60 years old. The CLHNS is an important cohort for the study of aging in the context of the rapid economic and health transitions characterizing much of the developing world.